Indication:
Dosage & Administration:
Tinea corporis, Tinea cruris: Tablet/Capsule: 100 mg once daily for 15 days or 200 mg once daily for 07 days; Solution: Child 1 month–11 years: 3–5 mg/kg once daily (max. per dose 100 mg) for 15 days.
Child 12–17 years: 100 mg once daily for 15 days, alternatively 200 mg once daily for 7 days. Tinea pedis, Tinea manuum: Tablet/Capsule: 100 mg once daily for 30 days; Solution: Child 1 month–11 years: 3–5 mg/kg once daily (max. per dose 100 mg) for 30 days. Child 12–17 years: 100 mg once daily for 30 days, alternatively 200 mg twice daily for 7 days. Tinea capitis: Child 1–17 years: 3–5 mg/kg once daily (max. per dose 200 mg) for 2–6 weeks. Onychomycosis: Tablet/Capsule: Either 200 mg daily for 3 months or course (pulse) of 200 mg twice daily for 7 days, subsequent courses repeated after 21 days’ interval. Fingernails two courses, toenails three courses. Solution: Child 1–11 years: 5 mg/kg daily (max. per dose 200 mg) for 7 days, subsequent courses repeated after 21-day intervals; fingernails 2 courses, toenails 3 courses. Child 12–17 years: 200 mg once daily for 3 months, alternatively 200 mg twice daily for 7 days, subsequent courses repeated after 21-day intervals; fingernails 2 courses, toenails 3 courses. Pityriasis versicolor: Tablet/Capsule: 200 mg once daily for 07 days; Solution: Child 1 month–11 years: 3–5 mg/kg once daily (max. per dose 200 mg) for 7 days. Child 12–17 years: 200 mg once daily for 7 days. Oropharyngeal candidiasis: Tablet/Capsule: 100 mg once daily for 15 days, increase dose to 200 mg once daily for 15 days in AIDS or neutropenic patients because of impaired absorption in these groups. Solution: Child 1 month–11 years: 3–5 mg/kg once daily for 15 days; maximum 100 mg per day. Child 12–17 years: 100 mg once daily for 15 days. Systemic candidiasis: Tablet/Capsule: 100-200 mg once daily for 3 weeks-7 months. Increase dose to 200 mg twice daily in case of invasive or disseminated disease; Solution: Child: 5 mg/kg once daily (max. per dose 200 mg), dose increased in invasive or disseminated disease and in Cryptococcal meningitis, increased to 5 mg/kg twice daily (max. per dose 200 mg). Vulvovaginal candidiasis: Tablet/Capsule: 200 mg twice daily for 01 days. Aspergillosis: Tablet/Capsule: 200 mg once daily for 2-5 months Increase dose to 200 mg twice daily in case of invasive or disseminated disease; Solution: Child: 5 mg/kg once daily (max. per dose 200 mg), increased to 5 mg/kg twice daily (max. per dose 200 mg), dose increased in invasive or disseminated disease and in cryptococcal meningitis. Systemic cryptococcosis including cryptococcal meningitis: Tablet/Capsule: 200 mg twice daily for 2-6 months; Solution: Child: 5 mg/kg once daily (max. per dose 200 mg), dose increased in invasive or disseminated disease and in cryptococcal meningitis, increased to 5 mg/kg twice daily (max. per dose 200 mg). Histoplasmosis: Tablet/Capsule: 200 mg once daily-twice daily for 8 months; Solution: Child: 5 mg/kg 1–2 times a day (max. per dose 200 mg). Maintenance in AIDS: Tablet/Capsule: 200 mg once daily until immune recovery; Solution: Child: 5 mg/kg once daily (max. per dose 200 mg), then increased to 5 mg/kg twice daily (max. per dose 200 mg), dose increased only if low plasma Itraconazole concentration. Prophylaxis in neutropenia: Tablet/Capsule: 200 mg once daily until immune recovery; Child: 2.5 mg/kg twice daily, to be started before transplantation or before chemotherapy (taking care to avoid interaction with cytotoxic drugs) and continued until neutrophil count recovers, safety and efficacy not established.
Preparation:
Itra® 200 Tablet: Box containing 18 tablets in Alu-Alu blister.
Itra® Oral Solution: Each bottle contains 100 ml solution with a measuring cup.
