Indication:
Dosage & Administration:
Suspension of this drug should be freshly prepared and not to be stored beyond 24 hours. The intensity and duration of therapy depend upon the severity and resistance of hyperkalemia.
Adults (including the elderly): Oral Dose: 15 gm to 60 gm (1 Sachet 1-4 times daily). Rectal dose: In patients who are unable to intake this medicine orally, rectal administration is possible (as enema). 30 gm to 50 gm of resin is given once or twice daily (at intervals of 6 hours). Each dose is administered as a warm emulsion (at body temperature) in 150 ml to 200 ml of aqueous vehicle (such as plain water, 10% dextrose in water or equal parts of water and 2% Methylcellulose suspension). The emulsion should be agitated gently during administration.
Children: Oral dose: Initial dose is 1 gm/kg body weight daily in divided doses in acute hyperkalemia. For maintenance therapy, dosage may be reduced to 0.5 gm/kg body weight daily. Rectal dose: When refused by mouth, the resin may be given rectally using a dose at least as much as that which would have been given orally. Neonates: Rectal dose: Since it is advised that the oral route should not be employed, only rectal administration should be considered. With rectal administration, the minimum effective dosage within the range of 0.5 to 1 gm/kg of resin should be employed. The resultant suspension should be diluted as for adults.
Mixing Procedure: Each dose should be given as a suspension in a small quantity of water or, for greater palatability, in sweetened liquid or syrup (but not with orange or other fruit juices which contain potassium). The amount of fluid usually ranges from 45 ml to 60 ml, depending on the dose. The prepared suspension should be administered by placing and maintaining the patient in an upright position.
Preparation:
